4-Fluorophenyl Methyl Sulfone
1-fluoro-4-(methylsulphonyl)benzene
CAS: 455-15-2
Molecular Formula: C7H7FO2S
4-Fluorophenyl Methyl Sulfone - Names and Identifiers
4-Fluorophenyl Methyl Sulfone - Physico-chemical Properties
| Molecular Formula | C7H7FO2S |
| Molar Mass | 174.19 |
| Density | 1.2768 (estimate) |
| Melting Point | 78-81 °C (lit.) |
| Boling Point | 95-97°C 7mm |
| Flash Point | 132.8°C |
| Solubility | Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol |
| Vapor Presure | 0.00261mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | Almost white |
| BRN | 2045674 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.507 |
| MDL | MFCD00039753 |
4-Fluorophenyl Methyl Sulfone - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29309090 |
| Hazard Class | IRRITANT |
4-Fluorophenyl Methyl Sulfone - Reference Information
| introduction | p-fluorobenzyl sulfone is a phenyl methyl sulfone derivative. Sulfone is a key organic structural element in a variety of bioactive molecules, drugs and synthetic intermediates. Sulfone compounds have broad-spectrum biological activities, such as insecticidal, bactericidal, herbicidal, anti-tumor, anti-virus, etc. |
| prepare | 500 mL flask with 25.2g of sodium sulfite, 100 mL of water and 16.8 g of sodium bicarbonate. After heating and refluxing, after all the solids are dissolved, add 21.0g of 4-fluorobenzenesulfonyl chloride in batches, and continue heating and refluxing for 4 hours. Cool to 40 ℃, add 18.9g of dimethyl sulfate dropwise from the separatory funnel, and the drop acceleration is appropriate to keep the system temperature at 40~45 ℃. After dropping, the heat preservation reaction was carried out for 2.5 hours, and after methylation reaction was complete, the heat reflux was carried out for 1 hour. Add 200mL of water, let it stand and cool to room temperature, precipitate a large amount of solids, filter, and wash with water to obtain p-fluorobenzene sulfone. |
Last Update：2024-04-10 22:29:15
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